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eXciteOSA® in Clinical Research

First Randomized Control Trial

Neuromuscular electrical stimulation for obstructive sleep apnoea: comparing adherence to active and sham therapy
 

A 2023 study concluded that daytime NMES (eXciteOSA®) was well accepted, with most users adhering to the recommended period. The treatment improved OSA severity and daytime sleepiness. Further research is needed to determine its role in treating various OSA severities and in patients intolerant to PAP therapy.

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Mechanistic Trial

The impact of daytime transoral neuromuscular stimulation on upper airway physiology – A mechanistic clinical investigation


A 2021 study showed positive results, including increased tongue endurance and improvements in the Pittsburgh Sleep Quality Index (PSQI) and psychomotor vigilance test (PVT), even in individuals with mild baseline flow-limited breathing.

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Multi-site Clinical Trial

Daytime Neuromuscular Electrical Therapy of Tongue Muscles in Improving Snoring in Individuals with Primary Snoring and Mild Obstructive Sleep Apnea


A 2020 study demonstrated that daytime NMES (eXciteOSA®) effectively reduces snoring and improves both patient and bed partner sleep quality, as well as patient daytime somnolence. The treatment showed consistent improvement in objective and subjective measures, was well tolerated, and had minimal transient side effects.

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Multi-site Trial Subset

Transoral awake state neuromuscular electrical stimulation therapy for mild obstructive sleep apnea


A 2020 study highlights eXciteOSA as a daytime therapy for obstructive sleep apnea (OSA) that is well-tolerated and widely accepted by patients. This treatment eliminates the need for an in situ device during sleep, resulting in reduced OSA severity, decreased snoring, and improved subjective sleep metrics, which can be particularly beneficial for those with mild OSA.

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Single-site Trial Subset

A novel intraoral neuromuscular stimulation device for treating sleep-disordered breathing

This prospective cohort study in 2019, demonstrates a notable improvement in both objective and subjective parameters of snoring and mild OSA in both simple snorers and patients with mild OSA. This device offers a safe and novel approach to reduce snoring and mild OSA by utilising intraoral neuromuscular electrical stimulation. 

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Proof of Concept

Intraoral electrical muscle stimulation in the treatment of snoring


The first signs of the effectiveness of intraoral muscle stimulation in snoring patients were shown in 2018. 

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